Cannabidiol

March 28, 2020

 

 

 

(CBD) is a metabolite of Cannabis sativa. It has relaxing, anticonvulsant, anti-dystonic, antioxidant, anti-inflammatory effects, promotes sleep and is relaxing against anxiety and panic. It has also been shown to reduce intraocular pressure and is a promising atypical antipsychotic.

 

CBD is the acronym for cannabidiol, metabolite of the most famous cannabis, of which it is the second most abundant substance, after THC. Unlike this, however, CBD is not psychoactive, does not create addiction and has significant relaxing, anti-inflammatory and pain-relieving properties, so as to arouse increasing interest from the scientific community. Thanks to its therapeutic potential, it is used to treat various problems and is the substance to which we refer when we speak of "therapeutic cannabis"

 

CBD enhances the analgesic efficacy of THC by prolonging its duration of action (by activating the serotonergic pathway at the level of the dorsal raphe) and at the same time reducing its side effects on heart rate, respiration and body temperature. 

 

In particular, CBD interacts as an antagonist towards the GPR55 receptors, towards the vanilloid receptors TRPV1 and TRPV2 and as an agonist towards receptors for serotonin 5-HT1a. Cannabidiol is also a non-specific antagonist of cannabinoid CB1 and CB2 receptors, μ-opioid (MOR) and δ-opioid (DOR) receptors and other neurotransmitters.

 

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